Brand Names: Nolvadex, tamoxifen, tamoxifen breast cancer, tamoxifen nolvadex, breast cancer tamoxifen, tamoxifen carcinogen, tamoxifen what is it used for, tamoxifen side effects, buy tamoxifen, tamoxifen nolvadex treatment instruction, tamoxifen and alcohol, side effects in nolvadex, nolvadex dosages, generic for nolvadex, tamoxifen nolvadex order fast canada
What is Tamoxifen
Antiestrogenic anticancer drug. Competitively inhibits estrogen receptors in target organs and tumors originating from those organs. The result is a set of (drug-receptor-cofactor transport), which after translocation to the nucleus prevents hypertrophy of cells that depend on estrogen regulation. It has a antigonadotropnym properties, inhibits the synthesis of Pg in the tumor tissue. Inhibits the progression of tumor stimulated by estrogen. The ability to block estrogen may persist for several weeks after a single dose. In addition, tamoxifen can induce ovulation in women in its absence, stimulating the release of GnRH from the hypothalamus, which stimulates the release of gonadotropic pituitary hormones. In men with oligospermia increases the concentration of LH and FSH, testosterone and estrogen in the blood serum. Tamoxifen and its metabolites, some (N-dezmetiltamoksifen, 4 gidroksitamoksifen) are potent inhibitors of mixed function oxidase system cytochrome P450 liver, but the clinical significance of these effects is not defined.
Tamoxifen 10mg
| Package | Price | Per Pill | Savings | Order |
| 10mg × 20 pills | $ 26.99 | $ 1.33 | $ 0.00 |  |
| 10mg × 30 pills | $ 38.99 | $ 1.30 | $ 0.90 | |
| 10mg × 60 pills | $ 66.99 | $ 1.11 | $ 13.20 | |
| 10mg × 90 pills | $ 89.99 | $ 1.00 | $ 29.70 | |
| 10mg × 120 pills | $ 108.99 | $ 0.91 | $ 50.40 | |
| 10mg × 180 pills | $ 141.99 | $ 0.79 | $ 97.20 | |
| 10mg × 270 pills | $ 188.99 | $ 0.70 | $ 170.10 | |
| 10mg × 360 pills | $ 237.99 | $ 0.66 | $ 241.20 | |
Tamoxifen 20mg
| Package | Price | Per Pill | Savings | Order |
| 20mg × 20 pills | $ 32.99 | $ 1.64 | $ 0.00 | |
| 20mg × 30 pills | $ 47.99 | $ 1.60 | $ 1.20 | |
| 20mg × 60 pills | $ 76.99 | $ 1.29 | $ 21.00 | |
| 20mg × 90 pills | $ 100.99 | $ 1.12 | $ 46.80 | |
| 20mg × 120 pills | $ 119.99 | $ 1.00 | $ 76.80 | |
| 20mg × 180 pills | $ 154.99 | $ 0.86 | $ 140.40 | |
| 20mg × 270 pills | $ 207.99 | $ 0.77 | $ 234.90 | |
Uses
Breast cancer (especially in menopause), breast cancer (including in men after castration), kidney cancer, melanoma and sarcoma of soft tissues containing estrogen receptors; ovarian cancer, endometrial cancer. Prostate cancer (with resistance to other drugs).
Characteristics:
Antiestrogenic anticancer drug. Competitively inhibits estrogen receptors in target organs and tumors originating from those organs. The result is a set of (drug-receptor-cofactor transport), which after translocation to the nucleus prevents hypertrophy of cells that depend on estrogen regulation. It has a antigonadotropnym properties, inhibits the synthesis of Pg in the tumor tissue. Inhibits the progression of tumor stimulated by estrogen. The ability to block estrogen may persist for several weeks after a single dose. In addition, tamoxifen can induce ovulation in women in its absence, stimulating the release of GnRH from the hypothalamus, which stimulates the release of gonadotropic pituitary hormones. In men with oligospermia increases the concentration of LH and FSH, testosterone and estrogen in the blood serum. Tamoxifen and its metabolites, some (N-dezmetiltamoksifen, 4 gidroksitamoksifen) are potent inhibitors of mixed function oxidase system cytochrome P450 liver, but the clinical significance of these effects is not defined.
Contraindications:
Hypersensitivity, pregnancy, lactation. Diseases of the eye (including cataracts), hyperlipidemia, leukopenia, thrombocytopenia, hypercalcemia, marked thrombophlebitis, thromboembolic disease (including history).
Side effects:
Ossalgiya, pain in the lesions, fever, loss of appetite, nausea, vomiting, constipation or diarrhea, in rare cases - fatty liver, cholestasis, hepatitis, skin flushing with a sensation of heat, leukopenia, thrombocytopenia, thrombosis, thromboembolism, thrombophlebitis; skin rash, dry skin, increasing the size of soft-tissue structures, sometimes accompanied by severe erythema, lesions and adjacent areas (usually resolves within 2 weeks), hypercalcemia, peripheral edema (fluid retention associated with), alopecia, weight gain, depression, headache , dizziness, myasthenia gravis, fatigue, drowsiness, confusion, loss of visual acuity, corneal opacity, cataract, retinopathy, optic neuritis. Women - endometrial hyperplasia, a reversible development of cystic tumors, vaginal discharge, metrorrhagia, dysmenorrhea, genital itching, amenorrhoea. Men - reduced potency and / or libido.Peredozirovka. Symptoms: increased side effects. Treatment: symptomatic. No specific antidote.
Dosage and administration:
Usually determined individually, depending on the evidence. Inside, in breast cancer, kidney - 20-40 mg 1-2 times a day (morning and evening), endometrium - 20-30 mg 1-2 times a day. On the course - 2.4-9.6, the Treatment for a long time (until evidence of disease progression), as effect lasts only against the background of the continuous application, if necessary, used in combination with radiation and cytostatic therapy. Tablets should be taken without chewing, with a small amount of liquid at one time in the morning or dividing the appropriate dose for 2 doses, morning and evening.
Cautions:
Before starting treatment, women should undergo a thorough gynecological (excluding pregnancy) and physical examination. Tamoxifen causes ovulation, increasing the risk of pregnancy, so women of childbearing age should use reliable methods of contraception (hormonal) during treatment and for 3 months after treatment. During therapy it is necessary to periodically monitor the performance of blood coagulation, the concentration of Ca2 + in the blood picture of the blood (white blood cells, platelets), liver function tests, blood pressure, conduct Eye check-ups - every 3 months, pelvic examination (with the appearance of vaginal bleeding or vaginal bleeding the drug should be discontinued.) In patients with bone metastases from time to time during the initial period of treatment should be to determine the concentration of Ca2 + in blood serum (in case of severe hypercalcaemia of tamoxifen should be suspended). Ineffective in treating patients with metastatic disease (especially liver). If signs of venous thrombosis of lower limbs (leg pain or swelling them), thromboembolic pulmonary artery branches (dyspnea), the drug should be discontinued. In patients with hyperlipidemia during treatment to monitor the concentration of cholesterol and triglycerides in the blood serum. During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require your full attention and psychomotor speed of reaction.
Interaction:
Enhances the effect of indirect anticoagulants (requires close monitoring for dose adjustment of anticoagulation). Cytotoxic drugs increase the risk of blood clots. Allopurinol promotes hepatotoxic effects. The combined use of tamoxifen and tegafur can cause chronic active hepatitis and cirrhosis. Concomitant use of tamoxifen with other hormonal drugs (particularly estrogen contraceptives) leads to a weakening of the specific effects of both drugs. Drugs that reduce excretion of Ca2 + (eg thiazide diuretics series), may increase the risk of hypercalcemia. Antacids, H2-blockers and histamine receptors dr.LS that reduce gastric acidity may cause premature dissolution, and loss of the protective effect of enteric tablets. Interval between doses of tamoxifen, and these drugs should be 1-2 hours
What does my medication look like?
Tamoxifen is available without a prescription under the brand name Nolvadex. Other brand or generic formulations may also be available. Ask your pharmacist to your questions about this medication, especially if it is new to you.
nolvadex tamoxifen, nolvadex tamoxifen citrate, arimidex tamoxifen, arimidex vs tamoxifen, tamoxifen vs arimidex, tamoxifen arimidex, femara vs tamoxifen, tamoxifen and ovarian cancer, arimidex versus tamoxifen, arimidex and tamoxifen, paxil and tamoxifen, effexor and tamoxifen, tamoxifen femara, tamoxifen vs femara, tamoxifen and effexor, tamoxifen versus arimidex, buy nolvadex tamoxifen citrate, does tamoxifen cause hair loss, tamoxifen and paxil, paxil tamoxifen, tamoxifen metastatic breast cancer, lexapro and tamoxifen, zoloft and tamoxifen, tamoxifen clomid, tamoxifen and zoloft, tamoxifen vs clomid, tamoxifen and lexapro, tamoxifen and arimidex, tamoxifen and wellbutrin, buy nolvadex tamoxifen.